人神经元细胞描述:
中枢神经系统的组织由两类细胞组成,可大致分为神经元和神经胶质细胞。神经元是大脑的解剖、功能和营养单位。尽管大小和形状存在很大差异,但所有神经元都具有共同的形态特征,这是高度复杂的通信网络的关键要素。神经元是动态极化的细胞,是神经系统的主要信号传导单元。人脑包含大约 1 x 10 ^11 个 神经元,每个神经元能够与至少 10,000 个其他神经元联系。
ScienCell 研究实验室的 HN 是从人脑中分离出来的。HN 在 P0 处冷冻保存并冷冻交付。每个小瓶在 1 ml 体积中含有 >1 x 10 ^6 个细胞。HN 的特征是使用 β-微管蛋白 III 特异性抗体进行免疫荧光。HN 的 HIV-1、HBV、HCV、支原体、细菌、酵母菌和真菌均为阴性。HN保证在ScienCell研究实验室提供的条件下进一步培养;然而,不建议将 HN 用于扩增或长期培养,因为细胞在培养中不会增殖。
推荐培养基:神经细胞培养基(NM, Cat. No. 1521)。
产品使用说明:仅供科研研究使用!
货号 | 1520 |
产地 | 美国 |
缩写 | HN |
规格 | 1 x 10^6 cells/vial |
用途 | 科研 |
运输 | 干冰 |
保存 | 液氮 |
5.) Chu S, Ma Y, Feng D, Li Z, Jiang P. (2013) "Predictive value of the SLC22A18 protein expression in glioblastoma patients receiving temozolomide therapy." J Transl Med. 11: 69.
7.) Deshmane SL, Mukerjee R, Fan S, Sawaya BE. (2011) "High-performance capillary electrophoresis for determining HIV-1 Tat protein in neurons." PLoS One. 6: e16148.
8.) Saiyed ZM, Gandhi N, Agudelo M, Napuri J, Samikkannu T, Reddy PV, Khatavkar P, Yndart A, Saxena SK, Nair MP. (2011) "HIV-1 Tat upregulates expression of histone deacetylase-2 (HDAC2) in human neurons: Implication for HIV-associated neurocognitive disorder (HAND)." Neurochem Int. 58: 656-64.
9.) Gouras GK, Tampellini D, Takahashi RH, Capetillo-Zarate E. (2010) "Intraneuronal beta-amyloid accumulation and synapse pathology in Alzheimer's disease." Acta Neuropathol. 119: 523-41.
10.) Mak YT, Lam WP, L L, Wong YW, Yew DT. (2010) "The toxic effect of ketamine on SH-SY5Y neuroblastoma cell line and human neuron." Microsc Res Tech. 73: 195-201.
11.) Lee CT, Lehrmann E, Hayashi T, Amable R, Tsai SY, Chen J, Sanchez JF, Shen J, Becker KG, Freed WJ. (2009) "Gene Expression Profiling Reveals Distinct Cocaine-Responsive Genes in Human Fetal CNS Cell Types." J Addict Med. 3: 218-26.
12.) Lee CT, Chen J, Hayashi T, Tsai SY, Sanchez JF, Errico SL, Amable R, Su TP, Lowe RH, Huestis MA, Shen J, Becker KG, Geller HM, Freed WJ. (2008) "A mechanism for the inhibition of neural progenitor cell proliferation by cocaine." PLoS Med. 5: e117
13.) Karmakar S, Banik NL, Patel SJ, Ray SK. (2007) "Garlic compounds induced calpain and intrinsic caspase cascade for apoptosis in human malignant neuroblastoma SH-SY5Y cells." Apoptosis. 12: 671-84.
14.) Michaelis M, Kleinschmidt MC, Doerr HW, Cinatl J Jr. (2007) "Minocycline inhibits West Nile virus replication and apoptosis in human neuronal cells." J Antimicrob Chemother. 60: 981-6.
15.) Cassiani-Ingoni R, Cabral ES, L?nemann JD, Garza Z, Magnus T, Gelderblom H, Munson PJ, Marques A, Martin R. (2006) "Borrelia burgdorferi induces TLR1 and TLR2 in human microglia and peripheral blood monocytes but differentially regulates HLA-Class II expresssion." Journal of Neupathology & Experimental Neurology. 65: 540-48.
16.) Padmanabhan J, Levy M, Dickson DW, Potter H. (2006) "Alpha1-antichymotrypsin, an inflammatory protein overexpressed in Alzheimer's disease brain, induces tau phosphorylation in neurons." Brain. 129: 3020-34.
17.) Hashimoto M, Bar-On P, Ho G, Takenouchi T, Rockenstein E, Crews L, Masliah E. (2004) "Synuclein Regulates Akt Activity in Neuronal Cells-a possible mechanism for neuroprotecton in parkinson's disease." J Biol Chem. 279: 23622-9.
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